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Abstract #0819

Normative growth models for T2w 0.55T fetal brain and body MRI: population-averaged 4D atlases and volumetry centiles

Alena Uus1,2, Jordina Aviles Verdera1,2, Kelly Payette1,2, Megan Hall2,3,4, Sara Neves Silva1,2, Kathleen Colford2, Aysha Luis2, Jacqueline Matthew1,2, Maria Deprez1,2, Sarah Mcelroy2, Joseph V. Hajnal1,2, Mary Rutherford2, Lisa Story2,3,4, and Jana Hutter1,2,5
1Department of Biomedical Engineering, King's College London, London, United Kingdom, 2Centre for the Developing Brain, King's College London, London, United Kingdom, 3Department of Women and Children’s Health, King's College London, London, United Kingdom, 4Fetal Medicine Unit, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, 5Radiological Institute, University Hospital Erlangen, Erlangen, Germany

Synopsis

Keywords: Fetal, Fetus

Motivation: Low field MRI is a promising direction for fetal imaging. Yet, there are no reported models of fetal development specific to 0.55T.

Goal(s): We aim to formalise normal fetal growth models for structural 0.55T MRI.

Approach: We use registration-based approach for generation of spatio-temporal templates from 3D D/SVR reconstructed images of the fetal brain and body and apply deep learning segmentation to parcellate organs for volumetry from >100 control subjects.

Results: This work introduces the first T2w fetal atlases and volumetry growth charts for 0.55T brain and body MRI depicting normal development across 22-38 weeks gestation. All models are publicly available online.

Impact: This work is the first step toward formalisation of analysis protocols for normal fetal brain and body development and optimisation of segmentation methods for low field strength fetal MRI.

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