Keywords: Liver, Fat, proton density fat fraction, quantitative, reproducibility, repeatability
Motivation: Performance assessment of PDFF in phantoms and in vivo, including linearity and bias, and reproducibility and repeatability, have largely focused between the range of 0-50%.
Goal(s): We analyzed PDFF performance in a two-site phantom study across the full 0-100% PDFF range.
Approach: We used commercially available quantitative 3D chemical-shift-encoded water-fat MRI pulse sequences across three vendors at 1.5T and 3T.
Results: Results demonstrate strong linearity and minimal bias {pooled slope and intercept for 1.5T=0.99 (95% CI: 0.981-0.997), 0.61 (0.17, 1.04); for 3T=1.00 (0.995, 1.005), 0.69 (0.39, 0.97)} of PDFF across 10 MRI systems. Pooled reproducibility coefficient (RDC) across 30 phantom exams was 3.92%.
Impact: PDFF across the 0-100% range can be reliably estimated with minimal bias and strong linearity using current commercial offerings from MRI vendors at 1.5T and 3T, with intra-scanner repeatability coefficient<2% (in PDFF%) and inter-scanner, inter-site, and inter-vendor RDC<4% (in PDFF%).
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