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Abstract #0837

Liver T1 Mapping in a Large Cohort of Healthy Subjects: Normal Ranges and Correlation with Age and Sex

Antonella Meloni1, Aldo Carnevale2, Paolo Gaio2, Vincenzo Positano1, Alessia Pepe3, Andrea Barison1, Giancarlo Todiere1, Chrysanthos Grigoratos1, Laura Pistoia1, Petra Keilberg1, Melchiore Giganti2, Filippo Cademartiri1, and Alberto Cossu2
1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2University of Ferrara, Ferrara, Italy, 3University of Padua, Padova, Italy

Synopsis

Keywords: Liver, Tissue Characterization, normal values

Motivation: To fully exploit the clinical potential of T1 mapping in liver disease detection, normal values should be established.

Goal(s): We defined normal ranges for native hepatic T1 values using a 1.5T General Electric scanner.

Approach: MOLLI sequences were acquired in 100 healthy volunteers and native T1 values were quantified in the visible hepatic segments.

Results: Segmental and global liver T1 values exhibited a good intra- and inter-observer reproducibility. A significant difference in the segmental T1 values was detected. Segmental and global T1 values were not associated with age and were comparable between males and females.

Impact: Liver T1 mapping is feasible and reproducible and the provided normal ranges may help to establish diagnosis and progression of various liver diseases.

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