Abstract #0844

Multiparametric MRI to study changes across the Surgical Journey in Bariatric Patients with Type 2 diabetes or Prediabetes.

Abi Spicer¹, Rebekah Wilmington^2,3, Stephen Lloyd-Brown^1,4, Chris Bradley^1,5, Martin Craig¹, Elizabeth J Simpson^5,6, Stephen J Bawden^1,5, Gerry McCann⁷, Guruprasad Aithal⁵, Penny Anne Gowland^1,5, Iskandar Idris^2,3, and Susan T Francis^1,5

¹Sir Peter Mansfield Imaging Centre,Physics, University of Nottingham, Nottingham, United Kingdom, ²Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Nottingham, United Kingdom, ³Bariatric Metabolic Institute, University Hospitals of Derby and Burton NHS foundation Trust, Derby, United Kingdom, ⁴Intelligent Modelling and Analysis, University of Nottingham, Nottingham, United Kingdom, ⁵National Institute for Health Research Biomedical Research Centre, Queen's Medical Centre and University of Nottingham, Nottingham, United Kingdom, ⁶David Green Human Physiology Unit, University of Nottingham, Nottingham, United Kingdom, ⁷Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Leicester, United Kingdom

Synopsis

Keywords: Liver, Diabetes, Bariatric, Pre-Diabetes, Liver, Pancreas, Spleen

Motivation: Bariatric surgery is evaluated by weight loss and diabetes remission, but the mechanism of the latter is unclear.

Goal(s): Use MRI to quantify changes in liver, pancreas and subcutaneous adipose tissue (SAT).

Approach: Multiparametric MRI of fat fraction (FF), T₂*, volume, T₁ and T₂ at four timepoints before and after bariatric surgery.

Results: Significant reduction in liver FF from baseline to 6-weeks, and between post-VLCD and 6-weeks, and liver volume from baseline to subsequent time points. Compared to baseline a significant increase in liver T₂* at 6-weeks, reduction in liver T₁ at 6-weeks and 6-months, and decrease in SAT at 6-months

Impact: Multiparametric MRI assessment of changes in liver and pancreas fat, volume and T₁, T₂* and T₂ relaxometry, as well as subcutaneous volume associated with bariatric surgery may serve as markers for longitudinal and cross-sectional assessment of patients.

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