Abstract #0846

Hepatic inflammation grading in diffuse liver disease using three-dimensional multifrequency MR elastography

Shan Cai^1,2, Christian Simonsson^2,3, Jens Tellman^1,2, Nils Dahlström^2,4, Simone Ignatova⁵, Stergios Kechagias⁶, Patrik Nasr⁶, Mattias Ekstedt⁶, Ralph Sinkus⁷, and Peter Lundberg^1,2

¹Department of Radiation Physics, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden, ³Department of Biomedical Engineering, Linköping University, Linköping, Sweden, ⁴Department of Radiology, and Department of and Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ⁵Department of Clinical Pathology and Clinical Genetics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden, ⁶Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ⁷Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Synopsis

Keywords: Liver, Inflammation, Diffuse liver disease, multifrequency MRE, 3D MRE

Motivation: Additional viscoelastic parameters measured using 3D multifrequency MRE have been reported to detect inflammation in the liver. However, a clinical cohort with multiple etiologies has not been well-studied.

Goal(s): Our goal was to determine the role of 3D multifrequency MRE for staging hepatic inflammation in diffuse liver disease with various etiologies.

Approach: Viscoelastic parameters were derived from 3D MRE with low, medium and high vibration frequencies, and compared with histological assessment.

Results: The moduli |G*|, G’ and G” and the exponent of power law γ were found to be associated with inflammation.

Impact: Three-dimensional multifrequency MRE, with its ability to provide additional viscoelastic parameters, could be a powerful tool for the non-invasive detection of inflammation activity in patients with diffuse liver disease.

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