Abstract #0847

Identifying Subvoxel Diamagnetic and Paramagnetic Components in Liver and Spleen Using DECOMPOSE-QSM

Asli Alpman¹, Jingjia Chen^2,3, Hongjiang Wei^4,5, and Chunlei Liu^1,6

¹Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ⁴School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁵The National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai, China, ⁶Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States

Synopsis

Keywords: Liver, Quantitative Susceptibility mapping

Motivation: Fibrotic liver, a condition that may cause cirrhosis if untreated, often contains both paramagnetic iron and diamagnetic collagen. While quantitative susceptibility mapping (QSM) calculates the voxel-wise tissue susceptibility, it cannot distinguish the competing effect of iron and collagen within a voxel.

Goal(s): The purpose of this work is to identify sub-voxel paramagnetic and diamagnetic susceptibility sources within the liver and spleen.

Approach: For this purpose, we applied the DECOMPOSE-QSM method to abdominal 1.5T MR images of patients with various levels of iron overload.

Results: The resulting paramagnetic and diamagnetic susceptibility maps demonstrated improved contrast compared to bulk susceptibility maps provided by QSM.

Impact: Identifying sub-voxel paramagnetic and diamagnetic sources within the liver through DECOMPOSE-QSM can facilitate the diagnosis of conditions such as liver fibrosis and hepatic iron overload.

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