Abstract #0849

In-vivo measurement of hepatic lipid composition with J-difference-editing-MRS

Yufan Zhou¹, Dingyi Lin¹, Jiaqiang Zhou², Shiyang You¹, Yang Cao¹, Chunli Cai³, Yi-Cheng Hsu⁴, Yuchen Zhao², and Min Wang^1,2

¹College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Endocrinology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China, ³Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China, ⁴MR Collaboration, Siemens Healthcare Ltd, Shanghai, China

Synopsis

Keywords: Liver, Metabolism, Lipid composition; J-difference-edited-MRS

Motivation: Hepatic lipid composition is important for diagnosis and prognosis of many hepatic diseases and for studying lipid metabolism.

Goal(s): This study aimed to apply J-difference-edited-MRS (JDE-MRS) for better measurement of hepatic lipid composition and evaluated its effectiveness in detecting lipid profile changes among metabolic disorders.

Approach: Hepatic lipid composition was measured and compared among healthy, NAFLD and T2DM human subjects using JDE-MRS under 3T, as well as among normal, obese and T2DM rat models using conventional MRS under 7T.

Results: The JDE-MRS application in human liver is reliable and the results shows differences between different groups, with similar results in rats.

Impact: This study demonstrates the feasibility of applying JDE-MRS in human liver, which can be used to quantify hepatic unsaturated lipid profile and can provide a reliable biomarker for clinical investigations of lipid metabolism in hepatic diseases.

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