Abstract #0884

Characterisation of cortical depth dependent hemodynamics in early human development using high-resolution BOLD fMRI at 7 Tesla.

Jucha Willers Moore^1,2,3, Elisabeth Pickles^4,5, Philippa Bridgen^4,5, Alena Uus^1,6, Ines Tomazinho^1,4, Beya Bonse^1,4, Maria Deprez^1,6, Sharon Giles^1,4,5, A. David Edwards^1,2,4, Jo V Hajnal^1,6, Shaihan J Malik^1,5,6, Tomoki Arichi^1,2,4, and Jonathan R Polimeni^3,7,8

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom, ²MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, ⁵London Collaborative Ultra high field System (LoCUS), King's College London, London, United Kingdom, ⁶Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁷Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁸Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: fMRI Analysis, High-Field MRI, Brain, Neuro

Motivation: Hemodynamic responses in adults vary across cortical depths, partly due to specific differences in vascular anatomy and physiology. It is unknown how these differences relate to the responses seen in neonates, when the cortex and neurovasculature are rapidly maturing.

Goal(s): To characterize the amplitude and timing of the hemodynamic response across cortical depths during the neonatal period.

Approach: Cortical depth-dependent hemodynamic responses to sensorimotor stimulation were delineated using GRE-BOLD fMRI in term-aged neonates.

Results: A cortical depth-specific profile of key hemodynamic response parameters, including onset and undershoot, was observed in the neonatal cortex that differs from those seen in the adult.

Impact: We demonstrate for the first time how developing vascular network may alter hemodynamic response across cortical depths. It illuminates what underlying neurobiology may generate the neonatal specific BOLD signal profile and what components are altered relative to the adult response.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.