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Abstract #0910

Leveraging unprecedented ultra-high strength gradients in commercially available MRI for in-vivo diffusion tensor CMR

Andrew D Scott1,2, Karl P Kunze3, Pedro F Ferreira1,2, Peter Speier4, Christian Geppert4, Dudley J Pennell1,2, and Sonia Nielles-Vallespin1,2
1CMR Unit, The Royal Brompton Hospital, London, United Kingdom, 2National Heart and Lung Institute, Imperial College London, London, United Kingdom, 3MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 4Cardiovascular MR Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Keywords: Gradients, Diffusion Tensor Imaging, ultra high gradient strength; motion compensated spin echo;

Motivation: Spin echo diffusion tensor cardiovascular magnetic resonance (DT-CMR) suffers from low SNR and resolution due to the time-consuming motion-compensated encoding gradients required.

Goal(s): Shorten TEs for motion compensated spin echo (MCSE) DT-CMR techniques to improve SNR and allow higher spatial resolution using ultra-high strength whole body gradients (200mT/m) newly available in commercially available scanners.

Approach: We implemented second order MCSE and acquired data in healthy subjects at peak systole and end diastole with maximum gradient strength of 146mT/m.

Results: We demonstrate high quality MCSE DT-CMR data with reduced TEs and higher spatial resolution than on previously available scanners using similar protocols.

Impact: Increases in imaging efficiency in DT-CMR enabled by the use of ultra-high strength gradients on commercial MRI systems will deliver shorter scans and improvements in spatial resolution which are vital steps on the road to clinical translation of DT-CMR.

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Keywords