Abstract #0919

MRI-based prediction of microvascular invasion or high tumor grade and adjuvant therapy benefit for solitary HCC ≤5 cm

Hanyu Jiang¹, Binrong Li², Tianying Zheng³, Yun Qin³, Zhenru Wu³, Maxime Ronot⁴, Victoria Chernyak⁵, Kathryn J. Fowler⁶, Mustafa R. Bashir⁷, Weixia Chen³, Yuan-Cheng Wang², Shenhong Ju², and Bin Song^3,8

¹Radiology, West China Hospital, Sichuan University, Chengdu, China, ²Zhongda Hospital, Southeast University, Nanjing, China, ³West China Hospital, Sichuan University, Chengdu, China, ⁴Hôpital Beaujon, Clichy, France, ⁵Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁶University of California San Diego, San Diego, CA, United States, ⁷Duke University Medical Center, Durham, NC, United States, ⁸Sanya People’s Hospital, Sanya, China

Synopsis

Keywords: Liver, Liver

Motivation: Noninvasive assessment of high-risk histopathology (microvascular invasion or Edmondson-Steiner G3/4) for early HCC is critical but challenging.

Goal(s): To develop an MRI-based diagnostic model for high-risk histopathology.

Approach: This dual-center retrospective study included consecutive patients who underwent contrast-enhanced MRI and subsequent curative resection or RFA for solitary BCLC 0/A HCC≤5 cm. A diagnostic model was developed against pathology based on resection-treated patients.

Results: 554 patients were included. Serum α-fetoprotein, non-simple nodular growth subtype, and the VICT2 trait constituted the model (testing center AUC, 0.828). Adjuvant therapies were associated with improved RFS (resection, P=.009; RFA, P=.009) for the model-positive patients.

Impact: This dual-center study developed and externally validated a diagnostic model which could effectively predict high-risk histopathology and adjuvant therapy benefit for patients receiving curative resection or radiofrequency ablation for solitary BCLC 0 or A HCCs ≤5 cm.

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