Keywords: Microstructure, Microstructure, brain, diffusion, microstructure, metabolites, DW-MRS, spines, gray matter, simulation
Motivation: Dendritic spines are fine microstructures increase the complexity of brain cells. Spines are characteristic morphological feature of neurons and their density can change with pathological conditions.
Goal(s): Quantification of dendritic spines in gray matter in human brain using diffusion-weighted MR spectroscopy
Approach: Using Monte-Carlo diffusion simulations for metabolites, to investigate how a dMRS signal is sensitive to the dendritic spines.
Results: Our findings suggests potential biomarkers for characterizing dendritic spines in human brain gray matter using diffusion-weighted MR spectroscopy
Impact: This work establishes a benchmark for spine sensitivity and quantification. Also it offers potential dMRS acquisition parameters for spine detection in human brain.
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