Abstract #0936

A new handle on extracellular diffusion and exchange? Single and double diffusion encoded MRS in humans after MSM ingestion

Henrik Lundell^1,2, Samira Bouyagoub³, André Döring^4,5, Nick G Dowell³, Roland Kreis^6,7, and Itamar Ronen³

¹Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark, ²Department of Health Technology, Technical University of Denmark, Lyngby, Denmark, ³Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom, ⁴CIBM Center for Biomedical Imaging, EPFL CIBM-AIT, EPFL Lausanne, Lausanne, Switzerland, ⁵Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁶Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, ⁷Translational Imaging Center, sitem-insel, Bern, Switzerland

Synopsis

Keywords: Microstructure, Microstructure

Motivation: The investigation of extracellular spaces with diffusion weighted MRI andMRS is limited by the ubiquitous distribution and fast exchange of water, while endogenous metabolites are mostly intracellular.

Goal(s): Investigate the diffusion characteristics of ingested MSM compared to water and endogenous metabolites.

Approach: Multi b-valued single and double diffusion encoded MRS in humans at 3T.

Results: MSM diffuses anisotropically, but considerably faster than intracellular metabolites, and exhibits a substantially different behavior compared to both water and metabolites.

Impact: MSM provides a novel probe of extracellular spaces similar to water but with differences that could be rotted in different transmembrane exchange properties.

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