Abstract #0957

Dynamic interleaved radial amine CEST and sodium (INTERLACED) at 3T

Alfredo Liubomir Lopez Kolkovsky^1,2,3, Chencai Wang^1,2, Jingwen Yao^1,2,4, and Benjamin M. Ellingson^1,2,5

¹Radiological Sciences, UCLA, Brain Tumor Imaging Laboratory, Los Angeles, CA, United States, ²Radiological Sciences, UCLA, Magnetic Resonance Research Laboratories, Los Angeles, CA, United States, ³NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, ⁴Bioengineering, UCLA, Los Angeles, CA, United States, ⁵Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States

Synopsis

Keywords: Data Acquisition, Non-Proton

Motivation: Sodium (²³Na) and advanced ¹H MRI provides valuable metabolic information but are not routinely used because of the required additional scan time.

Goal(s): Employ the idle times in ²³Na MRI to perform ¹H measurements, reducing total scan time.

Approach: An interleaved radial amine CEST and sodium pulse sequence was developed to simultaneously acquire acidity or T₂* maps simultaneously with salinity maps in phantoms and in the lower leg during an exercise paradigm.

Results: A scan reduction of 46% relative to sequential acquisitions. Dynamic T₂*, acidity and sodium changes were successfully tracked and in line with the expected physiological responses.

Impact: The achieved scan time reduction could facilitate the inclusion of sodium and advanced 1H imaging in clinical routine. Furthermore, it could benefit functional studies by providing dynamic multinuclear information simultaneously from the same transient state.

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