Keywords: Alzheimer's Disease, Alzheimer's Disease, Transcriptomic, 5xFAD
Motivation: While numerous studies noted the reduction of fractional anisotropy (FA) from diffusion MRI as a sensitive marker in Alzheimer's disease, the underlying biology remained elusive.
Goal(s): We aimed to explore biological basis of DTI metrics by integrating diffusion MRI with spatial transcriptomic data from the same individual.
Approach: We performed voxelwise correlation between the co-registered transcriptomic and MRI data and downstream enrichment analysis.
Results: We revealed links to myelin, oligodendrocytes, and Alzheimer's-associated biological processes.These findings enhanced our understanding of changes of diffusion MRI in Alzheimer's disease.
Impact: Spatial imaging-transcriptomic provides a certain level of biological evidence for the molecular processes underlying DTI signatures of Alzheimer’s disease. Similar approach can be applied to other types of MRI markers in different neurodegenerative diseases.
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