Abstract #0997

Distinct Effects of Respiratory Depth and Frequency on CSF Flow

Makaila N Banks^1,2,3, Harrison Fisher^2,3,4, Baarbod Ashenagar^2,4,5, Daniel E. P. Gomez^2,3,6, Jonathan R. Polimeni^2,6,7, Vitaly Napadow^2,3, and Laura D. Lewis^2,3,4

¹Graduate Program for Neuroscience, Boston University, Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Institute for Medical Engineering and Science, Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Department of Biomedical Engineering, Boston University, Boston, MA, United States, ⁵Institute for Medical Engineering and Science, Electrical Engineering and Computer Science, Massachusetts General Hospital, Cambridge, MA, United States, ⁶Department of Radiology, Harvard Medical School, Cambridge, MA, United States, ⁷Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Cerebrospinal Fluid Flow, CSF, phase contrast, velocity

Motivation: The flow of cerebrospinal fluid (CSF) is essential for maintenance of brain function.

Goal(s): We aimed to understand the effects of respiration on CSF flow dynamics by quantitatively testing the change in CSF flow across varying paced breathing frequencies.

Approach: Using flow-sensitive fMRI, phase contrast imaging, and physiological recordings, we measured changes in CSF flow and velocity during a visually guided paced breathing task.

Results: We examined CSF flow across breath frequencies ranging from 0.1 Hz to 0.25 Hz, and found that slower frequencies of breathing increase CSF flow, independent of breath depth.

Impact: Our results demonstrate that key features of human respiration, its timing and its depth, induce separate effects on CSF flow. Our identification of respiratory frequency as a modulator of CSF flow provides an accessible mechanism to modulate CSF flow.

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