Abstract #1053

Cortical Microhemorrhage Presentation of Small Vessel Primary Angiitis of the Central Nervous System

Ai Guo¹, Zhe Zhang¹, Ge-Hong Dong¹, Yuan Li², Lei Su³, Chenyang Gao³, Mengting Zhang¹, Xiaoyu Shi¹, Huabing Wang¹, Xinghu Zhang¹, De-Hong Lu¹, Ying Fu⁴, Jing Jing¹, Fu-Dong Shi¹, and De-cai Tian¹

¹Beijing Tiantan Hospital, Beijing, China, ²MR research collaboration team, siemens healthineers, Beijing, China, ³Tianjin General Hospital, Tianjin, China, ⁴The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

Synopsis

Keywords: Neuroinflammation, Neuroinflammation

Motivation: PACNS entails a biopsy for diagnosis, but only with an intermediate sensitivity. It is necessary to revisit PACNS with advanced imaging technique to provide a non-invasive diagnostic standard.

Goal(s): We aim to find more pathological details with enough sensitivity and specificity to provide potential biomarkers for PACNS.

Approach: 21 patients with small-vessel PACNS were included in this study. T1-MPRAGE, T2 T2*W, and SWI images were collected.

Results: Our study highlighted the image features of patients with small-vessel PACNS with coral-like signs through 7T MRI. Due to the small patient cohort, no specific clinical differences between hemorrhagic and non-hemorrhagic patients were found.

Impact: The signal characteristics of the coral-like sign represent cerebral cortical microhemorrhages with atrophy, which could be an important MRI pattern of small-vessel PACNS.

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