Abstract #1077

High-Fidelity Intravoxel Incoherent Motion (HIFIVIM) Parameter Mapping Using Locally Low-Rank with Temporal Subspace Constraint

Alan Finkelstein¹, Congyu Liao², Xiaozhi Cao², Merry Mani³, Giovanni Schifitto^4,5,6, and Jianhui Zhong^1,5,7

¹Department of Biomedical Engineering, University of Rochester, Rochester, NY, United States, ²Department of Radiology, Stanford University, Stanford, CA, United States, ³University of Iowa, Iowa City, IA, United States, ⁴Department of Neurology, University of Rochester, Rochester, NY, United States, ⁵Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁶Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, ⁷Department of Physics and Astronomy, University of Rochester, Rochester, NY, United States

Synopsis

Keywords: Image Reconstruction, Diffusion/other diffusion imaging techniques, Intravoxel Incoherent Motion, Model-Based Reconstruction, Subspace Reconstruction

Motivation: Intravoxel incoherent motion (IVIM) is a measure in MRI to quantify tissue perfusion. However, clinical applications are limited by noisy parameter estimates for the perfusion fraction (f) and pseudodiffusion coefficient (D*).

Goal(s): We sought to improve IVIM parameter estimation using a model-based reconstruction

Approach: We combined locally low-rank (LLR) and temporal subspace constraints to reliably perform joint reconstruction of IVIM images before fitting while correcting shot-to-shot phase variations between each b-value.

Results: Our method resulted in smoother signal decay curves before fitting and improved the estimation of IVIM parameter maps with less noise and fewer outliers.

Impact: A model-based reconstruction with low rank and temporal constraints improved IVIM image reconstruction, reducing noise and outliers in parameter estimates. Spline interpolation further facilitated reliable estimation of IVIM maps from just 5 b-values, benefiting clinical situations like stroke.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.