Abstract #1086
Non-invasive mapping of brown adipose tissue activity with MRI
Zimeng Cai1,2, Qiaoling Zhong3, Yanqiu Feng4,5,6, Zhigang Wu7, Changhong Liang1,2, Chong Wee Liew8, Lawrence Kazak9,10, Aaron M. Cypess11, Zaiyi Liu1,2, and Kejia Cai12,13
1Department of Radiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China, 2Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangzhou, China, 3Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China, 4School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 5Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China, 6Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence & Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, China, 7Philips Healthcare (Shenzhen) Ltd, Shenzhen, China, 8Physiology and Biophysics Department, University of Illinois at Chicago, Chicago, IL, United States, 9Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada, 10Department of Biochemistry, McGill University, Montreal, QC, Canada, 11Diabetes, Endocrinology, and Obesity Branch, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD, United States, 12Radiology Department, University of Illinois at Chicago, Chicago, IL, United States, 13Biomedical Engineering Department, University of llinois at Chicago, Chicago, IL, United States
Synopsis
Keywords: CEST / APT / NOE, Metabolism
Motivation: Through non-shivering thermogenesis, brown adipose tissue (BAT) plays a critical and beneficial role in obesity and metabolic diseases.
Goal(s): In this study, we developed non-invasive creatine CEST (CrCEST) MRI of adipose tissues for mapping BAT activity in both rodents and humans given to creatine’s important role in bioenergetics.
Approach: We observed by CrCEST MRI that the changes in BAT activity in rats and human after drug administration and/or cold exposure were in good agreement with traditional 18F-FDG PET/CT imaging.
Results: The results of this study demonstrated CrCEST MRI as an endogenous, non-invasive, and radiation-free method for in vivo mapping of BAT activity.
Impact: In this study, endogenous CrCEST MRI of adipose tissues was developed and found to serve as an imaging biomarker for BAT activity, the diagnosis of metabolic diseases, and the evaluation of new therapeutic strategies in a longitudinal and non-invasive means.
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