Abstract #1099

PET-MR compatible CEST method for imaging of Alzheimer’s Disease.

Rodolphe Leforestier¹, Ding Xia¹, Li Feng², Carolina Ferreira-Atuesta^3,4, Ziwei Xu⁴, Trey Hedden⁴, and Xiang Xu¹

¹Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New-York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), New York University Grossman School of Medicine, New-York, NY, United States, ³Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁴Department of Neurology, Icahn School of Medicine at Mount Sinai, New-York, NY, United States

Synopsis

Keywords: CEST / APT / NOE, CEST & MT

Motivation: Current methods of assessing Alzheimer's disease, such as PET scans, are expensive, involve exposure to radiation and have limited resolution.

Goal(s): We aim to demonstrate the applicability a novel CEST MRI method to measure the relayed Nuclear Overhauser effect, which may be sensitive to amyloid-β aggregates.

Approach: We have developed and tested a radially sampled CEST sequence (ssGraspCEST) that can be acquired on hybrid PET-MRI systems.

Results: MCI and AD patients appeared to have narrower distributions of LD_NOE and ∆ST(-3.6) and higher values. However, due to the limited sample size at this time, no significant differences were observed between the two groups.

Impact: We demonstrated the implementation of a fast, motion-robust CEST method, fully compatible with hybrid PET-MRI systems and particularly suitable for imaging elderly participants who cannot hold still during the scan, which may be useful in future for detecting pathological aggregates.

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