Abstract #1116

Multilevel clinical connectome fingerprinting: uncovering functional connectivity changes across the migraine cycle

Inês Esteves¹, Ana R. Fouto¹, Amparo Ruiz-Tagle¹, Gina Caetano¹, Rita G. Nunes¹, Nuno A. Silva², Pedro Vilela³, Raquel Gil-Gouveia⁴, Isabel Pavão Martins⁵, César Caballero-Gaudes⁶, and Patrícia Figueiredo¹

¹ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisboa, Portugal, ²Learning Health, Hospital da Luz, Lisboa, Portugal, ³Neurology Department, Hospital da Luz, Lisboa, Portugal, ⁴Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisboa, Portugal, ⁵Centro de Estudos Egas Moniz e Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa (FMUL), Lisboa, Portugal, ⁶Basque Center on Cognition, Brain and Language, Donostia, Spain

Synopsis

Keywords: Functional Connectivity, Brain, Migraine, Longitudinal, Multilevel Clinical Connectome Fingerprinting

Motivation: Case-control fMRI studies spanning the entire migraine cycle are lacking, precluding a complete assessment of brain functional connectivity in migraine. Such studies are essential for understanding the inherent changes in the brain of migraine patients as well as transient changes along the cycle.

Goal(s): Our goal was to determine the influence of the migraine cycle on individual functional connectome fingerprints.

Approach: Functional connectivity (FC) was longitudinally studied for migraine patients (across the four different cycle phases) and matched healthy controls.

Results: We observed greater heterogeneity in FC patterns of migraine patients and significant changes in FC across the cycle compared to controls.

Impact: This work represents the first case-control fMRI longitudinal study across the whole migraine cycle. Building upon clinical connectome fingerprinting, applied for the first time to migraine, it tackles a major cause of disability worldwide, contributing to developing connectome-based disease biomarkers.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.