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Abstract #1156

A Quantitative and Non-Invasive MR-based Method to Analyze Ventricular Shunt Flow in Patients with Hydrocephalus

Joseph H Ha1, Matthew T Borzage2, Eamon K Doyle3, Madison Gutierrez3, Jacob K Al-Husseini1, Meghan Drastal4, Isabel Torres3, J. Gordon McComb1, Stefan Blüml3, and Peter A Chiarelli1
1Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, United States, 2Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States, 3Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 4Children's Hospital Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Neuro, Brain, shunt, hydrocephalus

Motivation: We investigate a new approach to evaluating ventricular shunt function using phase-contrast magnetic resonance imaging (PC-MRI).

Goal(s): Our goal was to demonstrate the rapid (96-second) sequence as a practical adjunct for determining shunt function non-invasively.

Approach: An MRI phantom was constructed to assess CSF flows between 0-24 cc/hr while in vivo studies measured 21 consecutive patients.

Results: The PC-MRI calibration curve demonstrates a slightly non-linear relationship between flow output by pump and PC-MRI measured velocity. The in vivo patient studies flows ranged between 7 and 54 cc/hr.

Impact: Our work shows that PC-MRI is a non-invasive method for the measurement of CSF flow through the shunt in patients with hydrocephalus. Our work shows that PC-MRI is a promising addition to the clinical setting.

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Keywords