Abstract #1181

T1 measurement in CSF: Intrinsic compartmental differences and tracer concentration assessment in the healthy brain

Tryggve Holck Storås¹, Siri Fløgstad Svensson¹, Sofie Lysholm Lian², Geir Ringstad^3,4, Ingrid Mossige^1,2, Grethe Løvland⁵, Ragnhild Marie Undseth⁵, Kyrre Eeg Emblem¹, and Kaja Nordengen^2,6

¹Department for Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway, ²Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, ³Department of radiology, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, ⁴Department of Geriatrics and Internal Medicine, Sorlandet Hospital, Arendal, Norway, ⁵The Intervention Center, Oslo University Hospital, Oslo, Norway, ⁶Department of Neurology, Oslo University Hospital, Oslo, Norway

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: T1 mapping facilitates assessment of brain waste clearance by assessing native solutes or detection of endogenous tracers.

Goal(s): To provide a method for accurate measurement of T1 in CSF, to investigate variations in intrinsic T1 of CSF and to measure tracer in CSF after intrathecal administration.

Approach: A T2-weighted mixed spin-echo/inversion recovery sequence was implemented to measure T1 in CSF. Five healthy subjects were imaged prior to and four times after intrathecal gadobutrol injection.

Results: Baseline R1 is lower in the ventricles than in the subarachnoid space. At 72 hours after injection, there is still gadobutrol in the subarachnoid space.

Impact: Accurate T1 measurements in CSF facilitate quantitative study of brain clearance as concentration of Gd-based tracers in CSF can be established. Observed compartmental differences in intrinsic T1 of CSF indicate information on solute concentrations can be measured without endogenous tracer.

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