Keywords: Neurofluids, Neurofluids, Glymphatics
Motivation: CSF-mediated brain waste clearance is implicated in proteinopathies such as Alzheimer’s disease. A better understanding of clearance mechanics is needed to understand pathological processes.
Goal(s): To quantify flow- and pulsatility dynamics of CSF-motion in the 4th-ventricle using real-time phase contrast (rtPC) with interleaved BOLD-imaging while manipulating flow.
Approach: rtPC is first interleaved with inflow-sensitized EPI to prove the same CSF-fluctuations are captured. Then, we show BOLD-CSF coupling between rtPC and cortical BOLD as well as between inflow-EPI and cortical BOLD during breathing and visual-stimulation paradigms.
Results: rtPC improves characterization of CSF-flow in the 4th-ventricle compared to traditional BOLD-sequences, showing more coherent BOLD-CSF coupling.
Impact: Clinical MR studies are increasingly looking at changes in BOLD-CSF coupling in patient populations as a measure of brain clearance efficiency. By interleaving phase contrast acquisitions with BOLD, we quantify CSF flow dynamics and obtain more robust BOLD-CSF measurements.
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