Abstract #1188

Simultaneous 4D CSF flowmetry and BOLD fMRI using EPTI for investigation of neural activity evoked CSF flow responses

Fuyixue Wang^1,2, Timothy G. Reese^1,2, Bruce R. Rosen^1,2,3, Lawrence L. Wald^1,2,3, Laura D. Lewis^1,2,4, Jonathan R. Polimeni^1,2,3, and Zijing Dong^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Data Acquisition, fMRI Acquisition, CSF Flow

Motivation: To investigate brain-wide CSF flow dynamics and how neural activity drives it.

Goal(s): Develop a novel tool to simultaneously map CSF flow and T2*-BOLD fMRI with high sensitivity/specificity and effectively measure neural-activity-evoked CSF flow.

Approach: Single-shot PGSE-EPTI is developed with high sensitivity to slow flow to acquire distortion-free phase-contrast flow velocity and directions, while simultaneously obtaining clean T2*-BOLD, T2, S0 contrasts with improved specificity.

Results: Using the EPTI CSF flowmetry technique, brain-wide CSF dynamics were measured with high spatiotemporal details, and visual-task-evoked CSF flow responses were observed in both ventricles (global-response) and visual cortex subarachnoid space (local-response), synchronized with the simultaneously-acquired T2*-BOLD-fMRI signal.

Impact: We developed a novel EPTI CSF-flowmetry technique to simultaneously map whole-brain CSF flow and T2*-BOLD-fMRI with high sensitivity/specificity for investigation of neural-activity-driven CSF flow. It successfully measured both global and local visual-task-evoked CSF flow responses in ventricles and visual-cortex subarachnoid-space.

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