Abstract #1195

Synthetic CT generation using focal frequency loss improves image sharpness

Veronica Ravano^1,2,3, Adham Elwakil^1,2,3, Thomas Yu^1,2,3, Tom Hilbert^1,2,3, Bénédicte Maréchal^1,2,3, Jonas Richiardi², Jean-Philippe Thiran³, Charbel Mourad², Paul Margain⁴, Julien Favre⁴, Tobias Kober^1,2,3, Patrick Omoumi², and Stefan Sommer^1,5

¹Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Geneva and Zurich, Switzerland, ²Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁴Swiss Biomotion Lab, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁵Swiss Centre for Musculoskeletal Imaging (SCMI), Balgrist Campus, Zurich, Switzerland

Synopsis

Keywords: Analysis/Processing, Data Processing, synthetic CT

Motivation: Standard intensity-based voxel-wise losses, generally used in image-to-image translation techniques, are typically biased towards the estimation of the low frequency content in image spectra. For the generation of synthetic CT (sCT) contrast, this results in limited image sharpness, and consequently a limited clinical utility.

Goal(s): To improve sharpness in synthetic contrasts.

Approach: We trained a model using a combination of intensity- and frequency-based losses for the generation of sCT images from MRI.

Results: Compared to a baseline model, sCT images generated using the focal-frequency loss resulted in an enhanced level of details in knee images.

Impact: Our results suggest that the use of frequency-based losses, in conjunction with an intensity-based L1 loss, improves image sharpness in synthetic contrasts, and thereby shows the potential to increase their clinical usefulness.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.