Abstract #1214

Experimental reduction of peripheral nerve stimulation (PNS) using pre-excitation targeting of the potassium system (PRE-TAPS)

Natalie G. Ferris^1,2,3, Alex C. Barksdale^3,4, Valerie Klein^3,5, Bastien Guerin^3,5, Lawrence L. Wald^1,2,3,5, and Mathias Davids^3,5

¹Graduate Program in Biophysics, Harvard University, Cambridge, MA, United States, ²Harvard-MIT, Division of Health Sciences and Technology, Cambridge, MA, United States, ³A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ⁴EECS, MIT, Cambridge, MA, United States, ⁵Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Bioeffects & Magnetic Fields, Gradients, PNS thresholds, EM exposure, neurodynamic modeling, sequence development

Motivation: Peripheral nerve stimulation (PNS) limits the current generation of MRI gradient coils. We seek a sequence-based approach to improve scanner performance without hardware changes.

Goal(s): Experimentally demonstrate that pre-excitation targeting of the potassium system (PRE-TAPS) using a kHz-frequency preconditioner waveform can be used to increase PNS thresholds.

Approach: We measure changes in the PNS threshold of a 1.1kHz frequency probe waveform when a 10kHz preconditioner waveform is played immediately before the probe waveform and compare measured results to our model predictions.

Results: We found up to 10% greater PNS thresholds using PRE-TAPS in one subject and qualitative agreement with our PNS model.

Impact: Waveform-based modulation of PNS thresholds, such as pre-excitation targeting of the potassium system (PRE-TAPS) with a kHz-frequency preconditioner waveform, may enable increased performance in PNS-limited sequences such as EPI.

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