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Abstract #1233

RNN-aided metabolite quantification from incomplete FIDs in 1H-MRS of the brain

Eunho Jeong1, Joon Jang2, and Hyeonjin Kim3,4
1Department of Applied Bioengineering, Seoul National University Graduate School of Convergence Science and Technology, Seoul, Korea, Republic of, 2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of, 3Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, 4Department of Medical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of

Synopsis

Keywords: Analysis/Processing, Spectroscopy, Brain, Deep learning, Quantification, RNN

Motivation:
Incomplete FIDs can be obtained due to the limited sampling windows as in spectroscopic MRF and SSFP-MRSI, or due to FID truncation for removing spectral artifact.

Goal(s): Developing a means of quantifying metabolites from incomplete FIDs will allow more efficient sequence design and better experimental outcome.

Approach: We developed a recurrent-neural-network (RNN) for metabolite quantification from incomplete FIDs at 3.0T. The RNN was trained on simulated data and tested on in vivo data.

Results: Although the performance of the RNN requires further improvement for low concentration metabolites (e.g., GABA), it may allow quantification of the major metabolites under highly limited sampling windows.

Impact: Incomplete FIDs can be obtained due to the limited sampling windows as in spectroscopic MRF and SSFP-MRSI. We developed a recurrent-neural-network, which can quantify the major metabolites from the initial 64 FID data points, thereby allowing more efficient sequence design.

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Keywords