Abstract #1261

Sub-space Low-rank Imaging for mapping of blood-brain barrier Water Exchange Rate (SLIWER) using multi-PLD diffusion-weighted pCASL

Xingfeng Shao¹, Chenyang Zhao², Rong Guo^3,4, Qinyang Shou², Zhi-Pei Liang^4,5, Keith S St Lawrence^6,7, and Danny J.J. Wang²

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Arcadia, CA, United States, ²Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ³Siemens Medical Solutions USA, Inc., Urbana, IL, United States, ⁴Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Lawson Health Research Institute, London, ON, Canada, ⁷Department of Medical Biophysics, Western University, London, ON, Canada

Synopsis

Keywords: Arterial Spin Labelling, Permeability, Blood-brain barrier, water exchange, cerebral small vessel disease

Motivation: Non-invasive MRI mapping of the blood-brain barrier (BBB) function using water as an endogenous tracer can be a valuable tool for early detection of subtle BBB dysfunctions.

Goal(s): To develop an advanced MRI technique and reconstruction methods for reliable BBB water exchange rate (kw) mapping.

Approach: We introduce a Sub-space Low-rank Imaging method for mapping BBB Water Exchange Rate (SLIWER) with an innovative pulse sequence termed motion compensated diffusion weighted pCASL (MCDW-pCASL).

Results: The SLIWER method demonstrated high test-retest reliability, indicating its potential in clinical settings, such as in evaluating cerebral small vessel disease (cSVD).

Impact: We developed a reliable tool for early BBB dysfunction detection, potentially transforming the diagnosis and treatment of neurological disorders such as cerebral small vessel disease.

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