Abstract #1264

Iso-1.25mm Whole-cerebrum pCASL at 7T for Mapping Depth-dependent Cortical Gray Matter and Tract-specific White Matter Cerebral Blood Flow

Chenyang Zhao¹, Fanhua Guo¹, Qinyang Shou¹, Xingfeng Shao¹, Yuan Li², Shuo Huang², Yonggang Shi², and Danny JJ Wang^1,3

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Neuro Image Computing Research (NICR), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ³Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, 7T, Compressed Sensing

Motivation: Mapping CBF in the whole cerebrum extent at a microvascular level at 7T has been hampered by SNR, susceptibility artifacts, BOLD effect, and field inhomogeneity.

Goal(s): We aim to achieve an isotropic 1.25 whole cerebrum pCASL imaging.

Approach: We developed a pCASL sequence which incorporates recent optimizations of labeling and background suppression and a 3D TFL readout. Poisson-disc undersampling and compressed sensing were used to improve image quality.

Results: CBF mapping with high SNR and resolution was achieved, revealing depth-dependent CBF and an inverse relationship between tract-specific CBF and fractional anisotropy.

Impact: The proposed pCASL imaging technique will impact neuroscientists by enabling fine-grained mapping of CBF at microvascular level in cortical gray matter and white matter at 7T.

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