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Abstract #1269

ZOOM and enhance: ZOnally magnified Oblique Multi-slice for cardiac DTI with ultra-strong gradients

Lars Mueller1,2, Maryam Afzali1,2,3, Sam Coveney1, André Döring3,4, Fabrizio Fasano5,6, John Evans3, Irvin Teh1, Erica Dall'Armellina1, Filip Szczepankiewicz7, Derek K Jones3, and Jurgen E Schneider1
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 2These Authors contributed equally to this work, Leeds, United Kingdom, 3Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 4CIBM Center for Biomedical Imaging, EPFL CIBM-AIT, EPFL Lausanne, Lausanne, Switzerland, 5Siemens Healthcare Ltd, Camberly, United Kingdom, 6Siemens Healthcare GmbH, Erlangen, Germany, 7Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden

Synopsis

Keywords: Diffusion Acquisition, Diffusion Tensor Imaging, Cardiac diffusion MRI, strong gradients, ZOOM, reduced field of view, non co-planar rf

Motivation: Cardiac diffusion tensor imaging (cDTI) with echo-planar imaging (EPI) requires long readouts to avoid aliasing artefacts if 2D-selective rf-pulses are not available. These prolong the echo time (TE) and increasing sensitivity to off-resonance artefacts.

Goal(s): The reduction of the excited and refocused field of view in the phase direction to reduce TE and sensitivity to image artefacts in cDTI.

Approach: We combine ZOnally-magnified Oblique Multi-slice (ZOOM) EPI (i.e. tilting the slice orientation of the refocussing rf-pulse) with ultra-strong gradients.

Results: We were able to reduce TE (from ~70 ms to 59 ms) in cDTI considerably by reducing the FoV and using strong gradients.

Impact: We reduced the echo time in cDTI with ultra-strong gradients which will allow us to use more advanced diffusion acquisitions (higher b-values and/or different gradient waveforms) in the heart in vivo.

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Keywords