Keywords: Functional Connectivity, Quantitative Susceptibility mapping, Brain connectivity, resting-state fQSM
Motivation: Task-based functional Quantitative Susceptibility Mapping (fQSM) shows more localized brain activations than fMRI. Resting-state fMRI reveals brain connectivity networks but resting-state analysis of QSM has not yet been performed and may provide complementary information.
Goal(s): To perform a resting-state functional analysis using QSM (rsfQSM) and compare it to rsfMRI, focusing on the Default Mode Network (DMN).
Approach: We used seed-based and ICA-based analyses for rsfQSM and assessed the similarity of the DMN to that in rsfMRI with quantitative metrics.
Results: The DMN was detected in rsfQSM with spatial similarities to the DMN in rsfMRI. rsfQSM showed weaker and less extensive functional connectivity.
Impact: We computed resting-state functional connectivity from magnetic susceptibility maps for the first time, revealing similarities in the default-mode network compared to rsfMRI. This paves the way for new QSM-based explorations of brain function to potentially deepen understanding of neurological diseases.
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