Keywords: Relaxometry, Contrast Mechanisms, Paramagnetic Relaxation Enhancement; Rotational Correlation Time; Clinical MR Relaxometry
Motivation: This study exploits the underexplored potential of paramagnetic relaxation enhancement (PRE) in clinical MR scanners to characterize molecular interactions and tissue microenvironments in vivo, leveraging Gadolinium-based contrast agents (GBCAs).
Goal(s): Develop and validate methodology for estimating Gadolinium-based contrast agent (GBCA) correlation time via relaxivity ratio measurements at 1.5 and 3 Tesla.
Approach: Applying relaxation models, we devised a dictionary-matching framework correlating GBCA relaxivities with correlation times, and validated our methods using phantom experiments.
Results: Our framework accurately estimates GBCA correlation times at a single field strength showing <5% error (1.5T to 3T) and <11% (3T to 1.5T) in cross-field relaxivity predictions.
Impact: This framework leverages MR Relaxometry for precise estimation of GBCA rotational correlation time at single field strengths, offering insights in tissue characteristics. There is significant potential to improve tumor imaging and diagnosis through insights into pH, viscosity, and protein interactions .
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords