Abstract #1312

Blood-brain barrier breakdown in Alzheimer's disease and dementia with Lewy Bodies based on water exchange DCE-MRI

Ziming Xu¹, Jiaqi Dou¹, Jinghuan Gan², Zhichao Chen², Yajie Wang¹, Yong Ji³, and Huijun Chen¹

¹Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, Beijing, China, ²Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, Beijing, China, ³Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China, Tianjin, China

Synopsis

Keywords: Microstructure, DSC & DCE Perfusion, blood-brain barrier; Alzheimer's disease; dementia with Lewy bodies

Motivation: Transfer rate of contrast agent and water plays complementary role in assessing the integrity of blood-brain barrier, however there is currently no means of evaluating them simultaneously in dementia patients.

Goal(s): We aimed to develop a new pharmacokinetic model to comprehensively evaluate the blood-brain barrier damage in dementia patients.

Approach: Transfer rate of contrast agent and water was calculated based on a new pharmacokinetic model by simultaneous fitting of the Bloch–McConnell equation and the Patlak model.

Results: The proposed model was able to exhibit distinct patterns of blood-brain barrier damage in different types of dementia, which was significantly associated with cognitive impairment.

Impact: The transfer rate of contrast agent and water based on water exchange DCE-MRI demonstrated distinct patterns of blood-brain barrier damage in patients with Alzheimer’s disease and dementia with Lewy bodies, providing promising new non-invasive imaging biomarkers for dementia.

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