Abstract #1326

Preliminary investigation of BOLD dependence on EEG-TMS using a closed-loop TMS-EEG-fMRI setup

Joonas Petteri Laurinoja^1,2, Umair Hassan³, Mikko Nyrhinen², Matilda Makkonen², Pantelis Lioumis², Fa-Hsuan Lin⁴, Christoph Zrenner⁵, Risto Ilmoniemi², and Dogu Baran Aydogan⁶

¹A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, HELSINKI, Finland, ²Dept. of Neuroscience and Biomed. Engineering, Aalto University, Espoo, Finland, ³Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, United States, ⁴Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada, ⁵Centre of Addiction and Mental Health, University of Toronto, Toronto, ON, Canada, ⁶A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

Synopsis

Keywords: Hybrid & Novel Systems Technology, Multimodal, TMS, EEG, fMRI

Motivation: The motivation for this research study is to improve the efficacy of transcranial magnetic stimulation.

Goal(s): The specific goals of this study are to establish a closed-loop TMS-EEG-fMRI system and to investigate brain state-dependent EEG-TMS responses in relation to concurrent fMRI measurements.

Approach: 150 single TMS pulses are delivered while monitoring TMS-elicited network activity using interleaved fMRI acquisition. Data processing involves extracting EEG phase information, preprocessing of fMRI data, and statistical analysis using SPM12.

Results: Significantly increased fMRI signal was detected in the M1 and SMA under specific EEG phase conditions. These results illustrate the relationship between TMS, EEG phases, and BOLD responses

Impact: The results of this study have important implications for the field of non-invasive brain stimulation and neuroimaging. The development of a closed-loop TMS-EEG-fMRI system holds the potential to revolutionize the treatment of various brain disorders by personalizing TMS interventions.

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