Abstract #1347

Analysis of Bolus Arrival Time in Moyamoya Disease Using Ultra-Fast 3D Dynamic Contrast-Enhanced MR Imaging by GRASP technique

Shuichi Ito¹, Sachi Okuchi¹, Yasutaka Fushimi¹, Koji Fujimoto², Satoshi Nakajima¹, Akihiko Sakata¹, Sayo Otani¹, Azusa Sakurama¹, Hiroshi Tagawa¹, Yang Wang¹, Satoshi Ikeda¹, Masaki Umehana¹, Yongping Ma¹, Takeshi Funaki³, and Yuji Nakamoto¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Department of Advanced Imaging in Medical Magnetic Resonance, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Synopsis

Keywords: Blood Vessels, DSC & DCE Perfusion, GRASP technique, Moyamoya disease

Motivation: To better understand the hemodynamics in moyamoya disease (MMD), high temporal and spatial resolution DCE-MRI using GRASP technique could estimate bolus arrival time (BAT) in MMD.

Goal(s): To find optimal condition for measuring BAT and to elucidate clinical value of BAT on MMD.

Approach: Thirty-seven MMD patients were included. Images with 5, 8, 13, and 21 spokes/frame were post-processed to derive time-intensity curves and estimate BATs.

Results: Using the optimal 13 spokes/frame, BATs were delayed on the side with severe stenosis/occlusion and were in the order of MCA M2, basal ganglia, thalamus, and choroid plexus.

Impact: Bolus arrival time in moyamoya disease estimated by using high temporal and spatial resolution 3D dynamic contrast-enhanced MR imaging using GRASP technique facilitates our understanding of the hemodynamics in moyamoya disease by elucidating regional difference.

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