Abstract #1349

Identification of constitutive parameters of carotid atherosclerotic plaques by CINE MR imaging

Rui Shen¹, Xinyu Tong¹, Huiyu Qiao¹, Ran Huo², Tao Wang³, Zuoguan Chen⁴, Ning Xu¹, Jiachen Liu¹, Shuwan Yu¹, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²Department of Radiology, Peking University Third Hospital, Beijing, China, ³Department of Neurosurgery, Peking University Third Hospital, Beijing, China, ⁴Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

Synopsis

Keywords: Vessel Wall, Atherosclerosis, mechanical constitutive property, inverse problem

Motivation: Beyond structural features of carotid plaque and hemodynamic parameters, the hemodynamic and structural metrics were determined by image-based computer simulations and the constitutive characteristics of carotid plaques were ignored.

Goal(s): We aimed to propose a method for identification of carotid plaque constitutive parameters using CINE MR images.

Approach: A novel MRI-based method to identify constitutive parameters of carotid plaque compositions was proposed and the calculated values from the proposed method were compared with the reference and ex-vivo validation.

Results: We found that calculated values were consistent with the reference and experimental results. The constant D₂ could identify plaque compositions with different stiffness.

Impact: Our study proposed a novel MRI-based method for identifying constitutive parameters of carotid plaque compositions. The constant D2 could indicate different components of carotid plaques.

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