Abstract #1355

High Fidelity Imaging of Tissue Heterogeneity, Micro-Anisotropy and Diffusion-Time Effects in Prostate Cancer

Malwina Molendowska^1,2, Maria Engel², Lars Müller^2,3, Samo Lasic^4,5, Derek K Jones², Chantal MW Tax^2,6, and Filip Szczepankiewicz¹

¹Medical Radiation Physics, Lund University, Lund, Sweden, ²Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, ³Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, ⁴Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark, ⁵Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden, ⁶Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Microstructure, Microstructure, Signal Representations, Prostate

Motivation: Clinical diffusion MRI for prostate cancer diagnosis has limited sensitivity and specificity to heterogenous microstructural changes.

Goal(s): Quantify time-dependent diffusion and diffusional variance at a high spatial resolution in human prostate in vivo.

Approach: The diffusion encoding waveforms were tailored to probe micro-anisotropy and diffusion time effects at high b-values. Ultra-strong gradients and spiral readout enabled high-resolution and high image fidelity at a high SNR.

Results: Significant time-dependent diffusion was observed in all diffusion parameters in three volunteers, including prostate cancer patients.

Impact: The proposed methodology enables evaluation of microscopic anisotropy and time-dependent diffusion in the prostate and provides insights into how dMRI should be interpreted at low and high b-values. The produced diffusion parameters may serve as biomarker candidates in future studies.

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