Abstract #1364

Time-dependent diffusion MRI-based microstructural mapping for preoperative prediction of intraductal component in invasive breast cancer

Hao Xu¹, Heping Deng¹, Jieke Liu¹, Meining Chen², Thorsten Feiweier³, and Peng Zhou¹

¹Department of Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Chengdu, China, ²MR Research Collaboration, Siemens Healthineers Ltd, Chengdu, China, ³Siemens Healthineers AG, Erlangen, Germany

Synopsis

Keywords: Microstructure, Quantitative Imaging

Motivation: Conventional MRI falls short in detecting specific imaging markers for an intraductal component(ductal carcinoma in situ) in invasive breast cancer (IBC-IC), thus affecting breast-conserving surgery. Advanced MRI techniques can help in preoperative evaluations.

Goal(s): We evaluated the efficacy of td-dMRI for preoperatively identifying IBC-IC for surgical planning.

Approach: We used td-dMRI to examine microstructural mapping in IBC patients by IMPULSED model, focusing on the parameters D_ex, d, and v_in to differentiate IBC-IC from IBC.

Results: We revealed that elevated d and D_ex and reduced v_in are distinct microstructural markers of IBC-IC, which might facilitate surgical planning for IBC-IC patients.

Impact: Parameters derived from td-dMRI have the potential to act as imaging biomarkers for distinguishing IBC-IC, thereby enhancing the precision of breast-conserving surgery planning.

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