Meeting Banner
Abstract #1388

Whole Heart, Whole Cardiac Cycle, Motion-Resolved, 3D T2*-Mapping Reveals Myocardial T2* Differences Between Wild-Type and HCM Mice

Shahriar Shalikar1, Archana Malagi2, Xingmin Guan3, Yuheng Huang3,4, Oumaima Laghzali1,5, Chia-Chi Yang2, Rohan Dharmakumar6, Sonia Waiczies1, Thoralf Niendorf1,5,7, Hsin-Jung Yang2, and Min-Chi Ku1,5
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3School of Medicine, Indiana University, Indianapolis, IN, United States, 4Department of Bioengineering, University of California- Los Angeles (UCLA), Los Angeles, CA, United States, 5DZHK (German Centre for Cardiovascular Research), Berlin, Germany, 6Krannert Cardiovascular Research Center, Indiana University, Indianapolis, IN, United States, 7Experimental and Clinical Research Center, Charité—Universitätsmedizin Berlin, Berlin, Germany

Synopsis

Keywords: Myocardium, Animals, Relaxometry, T2*, Motion-resolved, Low-rank-tensor, Multi-echo

Motivation: To explore various stages of myocardial pathophysiology and improve prediction and interception of disease progression by capturing myocardial T2* variations across cardiac cycle.

Goal(s): To establish a framework that operates independently of ECG- and respiratory-gating, enabling cinematic, whole-heart myocardial T2*-mapping in mouse models.

Approach: A tailored framework was developed using modified Multi-Gradient-Echo (MGE) sequence and Low-Rank-Tensor (LRT) reconstruction technique. In vivo study was performed.

Results: Our preliminary findings demonstrate the feasibility of flow-compensated, free breathing, fully ungated, cardiac motion-resolved, whole heart and whole cardiac cycle coverage CINE imaging and T2* mapping in healthy and diseased mice heart.

Impact: The differences in myocardial T2* obtained for wild-type mice and HCM model provide a new metric ΔT2*,rel for myocardial tissue characterization, and springboard to inform on the different stages of myocardial pathophysiology and improve prediction and interception of disease progression.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract Presentation Video

Keywords