Keywords: Cancer, Breast, Triple-negative breast cancer; Non-triple-negative breast cancer; Amide proton transfer imaging; DWI
Motivation: Triple-negative breast cancer (TNBC) is a highly malignant and prognostically challenging subtype of breast cancer often elusive in conventional MRI scans [1.4.5]. Three-Dimensional Amide Proton Transfer Imaging (3D-APT), a non-invasive molecular imaging technique, shows promise in improving TNBC diagnosis.
Goal(s): This study aimed toinvestigate the diagnostic potential of 3D-APT, alone and in conjunction with diffusion-weighted imaging (DWI), in distinguishing TNBC from non-TNBC.
Approach: Quantitative analysis and comparison of APTw and DWI were conducted.
Results: Results revealed higher APTw and ADC values in TNBC compared to non-TNBC. Both APTw and DWI exhibit commendable diagnostic efficiency individually, while their combined application demonstrates superior discriminatory power.
Impact: These findings provide essential insights for tailoring individualized treatment strategies and assessing prognosis in clinical practice.
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