Abstract #1460

Restriction Spectrum Imaging (RSI) Models for Cervical Cancer

Ana Elvira Rodríguez-Soto¹, Christopher Conlin², Sheida Ebrahimi², Alexandra Besser², Stephan Jordan³, Elin Lundstrom², Alexandra Schlein³, Joshua Kuperman³, Anders Dale⁴, Tyler Seibert⁵, Michael McHale⁶, and Rebecca Rakow-Penner²

¹Radiology, University of California San Diego, San Diego, CA, United States, ²Radiology, University of California San Diego, La Jolla, CA, United States, ³University of California San Diego, La Jolla, CA, United States, ⁴Neurosciences, University of California San Diego, La Jolla, CA, United States, ⁵Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, United States, ⁶Ob/Gyn & Reproductive sciences, University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Cancer, Cancer

Motivation: Restriction spectrum imaging (RSI) has demonstrated potential to isolate cervical cancer signal from that of surrounding tissues. Women with post-treatment disease progression wait 3-6 months post treatment to get PET/CT exam to allow for edema/inflammation to subside. Cervical cancer-specific RSI model may allow us to evaluate response-to-treatment earlier.

Goal(s): The goal of this work was to develop an RSI cervical cancer model from a larger cohort of patients.

Approach: We used RSI-derived information from normal cervixes to convert RSI outputs to Z-score maps in cancer patients.

Results: Demonstrated the utility of RSI Z-score maps in differentiating cancers from healthy tissues without exogenous contrast.

Impact: Standard of care evaluation of cervical cancer response-to-treatment is PET/CT 3-6 months post-treatment to allow for edema/inflammation to subside. Cervical cancer-specific RSI model may allow us to evaluate response-to-treatment earlier and better inform patient treatment response without unnecessary delay.

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