Keywords: fMRI Acquisition, Breast, Amide proton transfer weighted imaging, Diffusion kurtosis imaging
Motivation: Breast Imaging Reporting and Data System (BI-RADS) is an internationally recognized scoring standard for the diagnosis of breast lesions, but it is highly subjective.
Goal(s): To evaluate the diagnostic performance of amide proton transfer weighted imaging (APTWI) and diffusion kurtosis imaging (DKI) in terms of differentiating breast lesions and to compare them with the BI-RADS independently or jointly.
Approach: Prospective cohort study
Results: APTWI and DKI can be used to distinguish breast lesions. The combination with APTWI and DKI can significantly improve the AUC values and specificity when compared with BI-RADS alone. The APTWI+DKI+BI-RADS has the best diagnostic performance in distinguishing breast lesions.
Impact: The combined APTWI and DKI outperformed BI-RADS alone in distinguishing benign and malignant breast lesions.
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