Abstract #1496

Cardiac Phantom-based Inter-site Calibration of T2, T1, and ECV Measurements

Carly Anne Lockard¹, Ruei-yuan Tu¹, Ke Yan², Aspen Duffin², Kimberly Crum³, Scott Auerbach⁴, Brian Fonseca⁴, Markus Renno⁵, Kenneth Knecht⁵, Margaret M Samyn², Jonathan Soslow³, and Bruce M Damon¹

¹Stephens Family Clinical Research Institute, Carle Clinical Imaging Research Program, Carle Foundation Hospital, Urbana, IL, United States, ²Medical College of Wisconsin, Milwaukee, WI, United States, ³Vanderbilt University, Nashville, TN, United States, ⁴Children’s Hospital Colorado, Denver, CO, United States, ⁵Arkansas Children’s Hospital, Little Rock, AR, United States

Synopsis

Keywords: Myocardium, Heart, Transplant, T1-mapping, T2-mapping, ECV, Rejection, Calibration

Motivation: Acute rejection is the leading cause of death in pediatric heart transplant (PHTx) recipients. Endomyocardial biopsy is currently required to monitor for rejection. Quantitative cardiac magnetic resonance (CMR) is a potential non-invasive monitoring tool, with T2, T1, and ECV mapping providing information about fibrosis and edema. However, measurements vary between sites.

Goal(s): To measure inter-site/temporal variability and calibrate multisite PHTx CMR data.

Approach: We investigated manganese-chloride solution cardiac phantom T2 and T1 repeatability and inter-site variation, and impact of calibration on PHTx data.

Results: Calibration reduced inter-site variability in phantom and PHTx measurements.

Impact: Our preliminary results illustrating inter-site variation in CMR-relevant phantom T2 and T1 measurements support the need for inter-site calibration when multi-center trials are conducted using CMR parametric imaging (T2, T1, and calculated ECV).

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