Abstract #1505

Quantitative, time-efficient viability CMR with delayed phase dynamic contrast-enhanced (dDCE) MRI

Li-Ting Huang^1,2, Xinheng Zhang^3,4, Xinqi Li², Archana Malagi², Yuheng Huang^4,5, Xinming Guan³, Ghazal Yoosefian³, Hao Ho⁶, Alan Kwan⁷, Anthony Christodoulou^2,4,8, Debiao Li², Hui Han², Yen-Wen Liu⁹, Rohan Dharmakumar^3,4, and Hsin-jung Yang²

¹Department of Medical Imaging, National Cheng Kung University Hospital, Tainan, Taiwan, ²Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ³Krannert Cardiovascular Research Center, Indiana University, Bloomington, IN, United States, ⁴Department of Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, IN, United States, ⁶Department of Statistics, University of California at Los Angeles, Los Angeles, CA, United States, ⁷Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁸Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁹Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

Synopsis

Keywords: Heart Failure, Cardiomyopathy, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)

Motivation: Late gadolinium enhancement (LGE) CMR‘s wider clinical adoption is hindered by its prolonged wait time and imaging protocol dependence.

Goal(s): Develop a delayed dynamic contrast enhancement (dDCE) model to shorten the LGE wait time and provide a quantitative characterization of the myocardium contrast washout process.

Approach: Dynamic T1 maps were acquired in the contrast washout period in dogs with myocardial infarctions. dDCE maps and synthesized LGE images were derived from data collected within 5-minute post-contrast injection.

Results: The 5-minute dDCE maps provide physiologically reasonable measurements and comparable myocardial viability assessment ability to standard LGE images.

Impact: The shortened LGE wait time from the quantitative dDCE maps may benefit patients unable to tolerate long CMR examination time and open new dimensions for quantitative myocardium viability assessment.

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