Keywords: Atherosclerosis, Cardiovascular, Myocardial Perfusion
Motivation: Model-based quantitative myocardial perfusion MRI is feasible. However, few studies have investigated its diagnostic accuracy in detecting significant coronary artery disease (CAD).
Goal(s): To evaluate the diagnostic accuracy of quantitative stress myocardial perfusion MRI using Patlak plot method for the detection of significant CAD.
Approach: Myocardial blood flow (MBF) and myocardial flow reserve (MFR) determined by Patlak analysis of stress perfusion MRI with LV blood saturation correction were compared with fractional flow reserve.
Results: Model-based quantitative stress perfusion MRI has a high diagnostic accuracy for detecting significant CAD with the AUC of 0.739 and 0.745 for stress MBF and MFR, respectively.
Impact: Absolute quantification of myocardial blood flow and myocardial flow reserve by stress-rest myocardial perfusion MRI with model-based approach permits accurate and objective assessment of myocardial ischemia due to flow-limiting obstructive coronary artery disease, which can aid daily routine clinical practice.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords