Abstract #1511

Quantification of Myocardial Blood Flow using Radial Simultaneous Multi-Slice Perfusion MRI

Lexiaozi Fan¹, Ye Tian², Ganesh Adluru^3,4, Jason Mendes³, Li-Yueh Hsu⁵, Jane E. Wilcox⁶, Edward DiBella^3,4, Daniel C. Lee⁶, and Daniel Kim^1,7

¹Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ²Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ³Utah Center for Advanced Imaging Research (UCAIR), Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, ⁴Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States, ⁵Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ⁶Division of Cardiology, Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ⁷Department of Biomedical Engineering, Northwestern University, Evanston, IL, United States

Synopsis

Keywords: Myocardium, Perfusion, Simultaneous multi-slice, myocardial blood flow

Motivation: While simultaneous multi-slice (SMS) excitation has been proposed to increase the myocardial coverage for cardiac perfusion MRI, its influence on the quantification of myocardial blood flow (MBF) has not been evaluated.

Goal(s): To determine whether SMS with multiband factor of two preserves accuracy in the quantification of MBF compared with the corresponding perfusion MRI with single-slice excitation.

Approach: We prospectively enrolled six patients and performed standard and SMS perfusion MRI back-to-back and calculated the arterial input function (AIF) and resting MBF.

Results: Both the AIF and MBF values calculated from the datasets acquired with the two perfusion sequences were comparable.

Impact: This study demonstrates feasibility of utilizing a 2D simultaneous multi-slice (SMS) (multiband factor = 2) perfusion sequence to increase the myocardial coverage and quantify the myocardial blood flow to help coronary artery disease diagnosis.

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