Abstract #1527

Multi-B-Values-Fitting RESOLVE DWI in Evaluation of Disease Activity and Curative Effect of Axial Spondyloarthritis (axSpA)

Xianyuan Chen¹, Shengsheng Yang¹, Mingui Lin², Fei Gao³, Mingping Ma¹, Shun Yu¹, and Yang Song⁴

¹Shengli Clinical Medical College of Fujian Medical University; Radiology department of Fujian Provincial Hospital, Fuzhou, China, ²Radiology department of Fuzhou Second Hospital, Fuzhou, China, ³Shengli Clinical Medical College of Fujian Medical University; Rheumatism department of Fujian Provincial Hospital, Fuzhou, China, ⁴MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China

Synopsis

Keywords: Bone, Diffusion/other diffusion imaging techniques, RESOLVE DWI; multi-b-values-fitting; axial spondyloarthritis; quantitative; tumour necrosis factor inhibitors

Motivation: Methods to quantitatively assess disease activity and efficacy of axSpA are still being explored.

Goal(s): To find a reliable quantitative indicator for evaluating disease activity and curative effect of axSpA, using multi-b-values-fitting RESOLVE DWI.

Approach: By comparing the ADC values calculated by fitting different b values between different groups, a relatively reliable b-values-fitting sequence was obtained, further evaluating curative effect of the treatment group in different cycles.

Results: Multi-b-values-fitting (b=50,500,700s/mm²) RESOLVE DWI has a certain advantage in evaluating disease activity and efficacy of axSpA, but the effect of short-term review (3 weeks or less) is unsatisfactory.

Impact: Multi-b-Values-Fitting RESOLVE DWI can differentiate the severity of axSpA disease activity more intuitively, by measuring the ADC values of bone marrow edema of sacroiliac joints, providing a new idea for clinical search for more objective and accurate quantitative parameters.

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