Abstract #1529

Validity of Ultrashort Echo Time MRI-based Finite Element Analysis of Human Femur Compared to Mechanical Testing

Kathryn Jaroszynski^1,2, Nada Kamona^1,2, Brandon C. Jones^1,2, Sandhya Konar¹, Makayla Clark¹, Michael Ispiryan¹, Michael Hast³, Snehal Shetye³, William Querido⁴, Nancy Pleshko⁴, and Chamith S. Rajapakse^1,3

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, United States, ⁴Bioengineering, Temple University, Philadelphia, PA, United States

Synopsis

Keywords: Bone, Bone

Motivation: Hip fractures pose a substantial health concern commonly associated with osteoporosis. Bone mineral density from Dual-energy X-ray absorptiometry (DXA) is the standard-of-care test for assessment of osteoporosis and fracture risk, yet many who sustain fragility fractures are above the diagnosis threshold.

Goal(s): The objective of this study was to conduct a preliminary investigation into the validity of MRI Finite Element Analysis (FEA) for predicting bone strength.

Approach: Ultrashort Echo Time MRI was used on cadaveric human femur sections and FEA was performed.

Results: The stiffness derived from UTE FEA showed a strong correlation with stiffness derived from mechanical testing.

Impact: This study compared UTE-based Finite Element Analysis to mechanical testing and found that there was a significant correlation between computational and experimental values. This indicates the potential for UTE MRI to be used in the clinical evaluation of bone strength.

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