Abstract #1554

Development of a whole spinal MRI-based tumor burden score method in participants with multiple myeloma: a pilot study of prognostic significance

sha cui¹, Yinnan Guo², Jianting Li¹, Wenjin Bian³, Wenqi Wu¹, Wenjia Zhang¹, Qian Zheng¹, Haonan Guan⁴, Jun Wang¹, and Jinliang Niu¹

¹Second Hospital of Shanxi Medical University, Taiyuan, China, ²Fifth hospital of Shanxi Medical University, Taiyuan, China, ³Shanxi Medical University, Taiyuan, China, ⁴GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Skeletal, MR Value

Motivation: Quantifying the extent of bone marrow infiltration or bone destruction plays a key role in assessing tumor burden and evaluating prognosis.

Goal(s): Previous semi-quantitative tumor burden scoring methods had limitations.

Approach: We developed a new whole spinal MRI-based tumor burden scoring method in participants with newly diagnosed multiple myeloma and to explore its prognostic significance by evaluating its role in predicting the early treatment response and its association with the R-ISS.

Results: The tumor burden score was an independent predictor of poor response and the AUC was 0.842. The tumor burden score was higher in R-ISS-III than in R-ISS-I and R-ISS-II.

Impact: This study quantified the extent of bone marrow infiltration or bone destruction in multiple myeloma and showed that high tumor burden scores were associated with poor early treatment response and high R-ISS stage.

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