Keywords: Other Musculoskeletal, PET/MR, back pain, molecular imaging
Motivation: Diagnosis of chronic low back pain remains a challenge with conventional diagnostic methods leading to unsatisfactory treatment in a vast majority of patients.
Goal(s): To investigate the use of sigma-1 receptor (S1R) radioligand, [18F] FTC-146 in conjunction with positron emission tomography/magnetic resonance imaging (PET/MRI) for identifying the pain generator in chronic low back pain.
Approach: Correlation of [18F] FTC-146 PET-MRI imaging in patients with unresolved chronic low back pain to clinical findings.
Results: S1R PET/MRI imaging matched the clinical diagnosis in all cases. Additionally, it offered benefit over traditional MRI by identifying additional “functional” findings both within and outside the spine.
Impact: Future clinical implementation of S1R-PET/MR can potentially help reveal previously unidentified pain generator in patients with chronic low back pain that have exhausted standard clinical care leading to better-targeted treatment.
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